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Patients with pre-existing gastrointestinal conditions, such as irritable bowel syndrome, may be more susceptible to these symptoms

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This effect is generally modest and clinically meaningful mainly for drugs with narrow therapeutic windows

Abbreviations A: Amyloid- NPY1R: Neuropeptide Y Y1 receptor VIP: Vasoactive intestinal peptide CRH : Corticotropin-Releasing Hormone ACTH : Adrenocorticotropic Hormone CCK: Cholecystokinin DSIP: Delta Sleep-Inducing Peptide GPCR: G protein-coupled receptors References Aguilera G (1994) Regulation of pituitary ACTH secretion during chronic stress

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